The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

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The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

The small GTPases of the Rho family are intimately involved in integrin-mediated changes in the actin cytoskeleton that accompany cell spreading and motility. The exact means by which the Rho family members elicit these changes is unclear. Here, we demonstrate that the interaction of paxillin via its LD4 motif with the putative ARF-GAP paxillin kinase linker (PKL) (Turner et al., 1999), is crit...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2001

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200101039